Dermatitis Herpetiformis
Dermatitis Herpetiformis Alternative name Duhring’s disease. Dermatitis herpetiformis is a prolonged ailment, extremely itchy rash having bumps and blisters. The disease is differentiated by the occurence of IgA deposits in the upper dermis skin and the diagnosis cannot be made in the absence of these deposits. The HLA-B8 gene is present in 80% of patients with gluten enteropathy and dermatitis herpetiformis.
Dermatitis herpetiformis is coupled to sensitivity of the intestine to gluten in the diet (celiac sprue). Dermatitis Herpetiformis is a disease of the skin. It is caused by deposition of IgA in the papillary dermis. This triggers an immune cascade, including recruitment of neutrophils and complement into the area. Dermatitis herpetiformis is an autoimmune burning complaint related with a gluten-sensitive enteropathy (GSE). It is clasiffied by grouped abrasion; erythematous, urticarial plaques; and papules having vesicles. There is effective evidence that the changes in the intestinal mucosa and the immunologic findings in most of the patients diagnosed with DH are alike with those found in celiac disease.
Dermatitis Herpetiformis has currently been suggested as a cutaneous manifestation of asymptomatic-to-mild CD. The genetic predisposition to the development of gluten sensitivity underlies the disease. Most DH patients can usually predict the location of a new lesion as much as 8 to 12 hours before the actual onset because of the symptoms of localized burning and itching.
Lesions occurring on the lips and within the mouth, it is extremely unusual for lesions to occur on mucous membranes (soft tissues at body openings) in other areas of the body. These lesions tend to occur in groups much like the lesions of Herpes, hence the term herpetiformis, meaning “like Herpes.” Because of the intense itching, the lesions are usually scratched; these affected areas will then mature crusts and then heal with changes in color, either those of hypopigmentation or hyperpigmentation. Lesions may first emerge as discolorations and next includes of small bumps called papules and small blisters called vesicles.
Causes of Dermatitis Herpetiformis
Common causes of Dermatitis Herpetiformis
- Triticeae.
- Gluten enteropathy.
- Gastric atrophy.
- Gastric hypochlorhydria.
- Pernicious anemia.
Symptoms of Dermatitis Herpetiformis
Common Symptoms of Dermatitis Herpetiformis
- Dry skin.
- Scratching.
- Clothing.
- Lesions.
- Itchy.
- Rash (bumps and blisters).
Treatment of Dermatitis Herpetiformis
Common Treatment of Dermatitis Herpetiformis
- Nonsteroidal anti-inflammatory drugs may exacerbate DH; however, ibuprofen appears to be safe.
li>Iodides may elicit or exacerbate DH. - Dapsone (diaminodiphenyl sulfone) and sulfapyridine are the primary medications used to treat DH.
Filed under: Skin Disorders